Overview
Electrochemical sensors rely on interactions at electrode surfaces to generate measurable signals in response to target analytes. Peptides are increasingly incorporated into these sensors because of their tunable selectivity, diverse sequence space, and capacity for specific binding interactions. By integrating peptides with electrode materials, researchers can design electrochemical systems that respond to defined molecular features in controlled environments.
Peptide-based sensors take advantage of sequence-controlled binding, where particular motifs or charged segments interact with analytes or surfaces in highly predictable ways. Advances in electrode modification, immobilization techniques, and signal amplification have further expanded the capabilities of these systems, making them valuable platforms for analytical science research.
Applications
- Peptide-modified electrodes – Electrodes coated with peptide layers provide selective interaction surfaces for analytes of interest.
- Selective electrochemical binding – Specific sequences are chosen to favor interactions that produce clear electrochemical responses.
- Signal-amplifying peptide layers – Structured arrangements of peptides help enhance sensor sensitivity through multi-point interactions or organized surface architectures.
- Analyte-targeting peptide sequences – Tailored peptides are used to enrich recognition for particular functional groups, charges, or structural motifs.
These research advances continue to enhance electrochemical sensor technology by utilizing peptide versatility to refine detection performance and analytical precision.